بررسی نقش کاندیدا در بیماری التهابی روده IBD در بیمارستان قائم مشهد 1403.
کد: G-1106
نویسندگان: Samira Zolfaghari Kheirabadi ℗, Mitra Ahadi, Somayeh Dolatabadi, Mohammad Javad Najafzadeh ©
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Background: Inflammatory bowel disease (IBD) including Crohn’s disease and ulcerative colitis. The pathogenesis (IBD), is related to the effect of fungal presence in the gastrointestinal tract (GI) on IBD development. Fungi recently play an important role in IBD. In this study, we used routine methods to determine and investigate different types of Candida in patients with IBD. And its help to highlight the future work to find a clear understanding of IBD pathogenesis. Methods: A stool sample was collected from patients with IBD (n25). Direct smear from stool and Calprotectin test was performed for IBD patients. We culture on Sc (sabouraud dextrose agar) medium containing antibiotics and kept in incubator for 72 h and the Fungus colony is inoculated with sterile inoculum in chrome Agar medium, after 48h based on color of the colonies and according to the guide of the manufacture of the medium ,we can detect candida species. Results: Of 25 samples, 22 of them had fungi (candida). Most people had Ulcerative colitis. There is an increased total fungal load particularly of Candida. The most frequently isolated species was C. albicans (no=9 ) in patients with IBD then Candida tropicalis (no=6) Candida Krusei (no=4) and Candida glabrata (no=3) were also observed in these patient. The Calprotectin test has increased significantly in affected people. Conclusions: Gut fungi are altered in patients with Crohn's disease and ulcerative colitis. Specific Candida taxa were found to be increased in abundance in the IBD samples. Future research should focus on understanding how the fungal microbiota interacts with other components of the gut microbiota in association with the pathogenesis and development of IBD. These data emphasize the importance of candida role in disease pathogenesis IBD. In addition, predictive value of fecal calprotectin for the response of IBD patients to a particular type of treatment and it can be very helpful.
کلمات کلیدی
Key Words: fungus, inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; Pathogenesis
