ارزیابی بازکاربرد دارو برای استافیلوکوکوس اورئوس: یک متاآنالیز شبکهای
کد: G-1113
نویسندگان: Mohammad Abavisani ℗, Alireza Khoshrou, Amirhossein Sahebkar ©
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Staphylococcus aureus is a major global health threat due to its increasing antibiotic resistance. The urgent need for alternative treatments has spurred interest in drug repositioning. This study aims to assess the efficacy of repositioned drugs in treating S. aureus infections by comparing survival outcomes in preclinical animal models. The current network meta-analysis (NMA) adhered to PRISMA guidelines, and, following the systematic searching, studies were selected based on their evaluation of non-antibiotic medications against S. aureus in animal models, providing survival assay data. Included studies were assessed for risk of bias using the SYRCLE tool. A random effects model was employed to compare drug effectiveness, with results presented as risk differences and ranked using P-scores. Out of 9042 records identified, 17 studies met the inclusion criteria. The majority of the studies (88.2%) used mice, with intraperitoneal infection models (41.1%) and anticancer drug categories (23.5%) being the most common. Several repositioned drugs showed significantly better survival rates compared to the negative control. Moreover, none of the treatments significantly outperformed the positive controls. Our analysis found that, compared to the negative and positive controls, oral FdUrd and isopropoxy benzene guanidine had the highest P scores (0.98 and 0.9, respectively). This NMA suggested that repositioned drugs may be effective against S. aureus and warrant further clinical testing.
کلمات کلیدی
Drug Evaluation, Preclinical; Drug Repositioning; Network Meta-Analysis; Staphylococcus aureus
