نقش سایتوکاین ها در پیشگویی عفونت های آینده در کودکان مبتلا به سرطان خون
کد: G-1119
نویسندگان: Ali Amanati ℗, Mehdi Kalani ©, Hossein Molavi Vardanjani, Mohebat Vali, Maral Choopanizadeh, Seyed Reza Abdipour Mehrian
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Introduction: Cytokines as important immune mediators are involved in determining the pathways of immune responses and consequently the disease outcomes. As biomarkers, cytokines have the potency to predict upcoming infections. The present study aimed to evaluate the predictive role of 12 cytokines corresponding to different T helper (Th) subsets in children who suffered from hematologic malignancies (HM). Materials and methods: Among 65 children suspected of HM, 49 and 16 were included in the study as the case and the control groups since HM just was confirmed in the cases but not in the controls. The blood samples were collected from the study groups at the onset of diagnosis, and cases post-chemotherapy induction, and during the chemotherapy maintenance phases. The sera were isolated and 12 cytokines were assessed using the flow cytometry method. The patients were followed up for 24 months for the presentation of infection and disease outcomes. Results: Baseline Th-related cytokines were significantly higher in the cancer-associated infection group compared to the infection-free control group. The concentrations of IL-2, IL-4, IL-6, and TNF-α were substantially higher in the patients with upcoming infection. Up-regulated IL-9 levels were associated with increased relapse and mortality. Conclusion: Higher baseline levels of cytokines in children with hematologic malignancies may be the consequence of microorganism colonization which could be useful for predicting imminent infections and disease outcomes. However, further studies with larger sample sizes are warranted.
کلمات کلیدی
Cytokine, Malignancy, Infection, Prediction, T helper subsets
