بررسی سطح گرلین در بیماران بزرگسال مبتلا به هلیکوباکتر پیلوری
کد: G-1148
نویسندگان: Seyedeh Azra Shamsdin ©, Hasti Samani ℗, Seyedeh Neda Shamsdin
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خلاصه مقاله:
خلاصه مقاله
Examination of Ghrelin Levels in Infected Adult with Helicobacter pylori Seyedeh Azra Shamsdin¹, Hasti Samani1, Seyedeh Neda Shamsdin ², 1 Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 2 Basic Sciences in infectious diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Abstract Introduction: Helicobacter pylori (H. pylori) is the main risk factor for stomach cancer and causes gastrointestinal diseases such as gastritis and peptic ulcer. ghrelin hormone plays a role in regulating feeding behavior, energy metabolism and gastric acid secretion. So far, several possible reports have been published about the relationship between ghrelin and gastric cancer, this study investigated the relationship between H. pylori infection as the main risk factor for stomach cancer and changes in serum ghrelin levels. Methods: The patients were selected with gastrointestinal symptoms and indigestion. 54 Adult patients whose Helicobacter tests (histopathology and rapid urease test) were positive and 36 Adult patients whose tests were negative. Serum ghrelin level was measured by ELISA method, p0.05 was considered as a statistically significant. Results: Ninety patients with gastrointestinal complaints were entered the study. Among the participants, (60%) women and (40%) were men. The average age of the population was 3711.5. Fifty-four were H. pylori infected and thirty-six non- infected. The serum level of ghrelin was significantly higher in the non-infected group. Among the clinic pathological indicators, two variables, hemoglobin and hematocrit were significantly higher in the patients with H. pylori infection compared with non-infected group (p0.05). Conclusion: The findings of this study indicated that the serum level of ghrelin in adult patients with H. pylori infection was statistically significantly lower than the non-infected group. The measurement of ghrelin in the serum may help in the follow-up of patients with Helicobacter pylori.
کلمات کلیدی
Key words: Serum, Ghrelin, Infection, H. pylori
