تاثیر داروی ضد افسردگی بر روی سایتوکاینها در بیماران مبتلا به هلیکوباکتر پیلوری
کد: G-1154
نویسندگان: Noshin Bashtani, Seyedeh Azra Shamsdin © ℗, Hajar Khazraei, Elham Moazamian, Hossein Faramarzi
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
The Effect of Anti-depressants on Cytokines in Patients with Helicobacter pylori Noshin Bashtani1, Seyedeh Azra Shamsdin2, Hajar Khazraei3, Elham Moazamian1, Hossein Faramarzi4 1-Department of Microbiology, College of Sciences, Agriculture and Modern Technology, Shiraz Branch, Islamic, Azad University, Shiraz, Iran 2- Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 3-Colorectal research center, Shiraz University of medical sciences, Shiraz, Iran 4-Department of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Introduction: Helicobacter pylori (H. pylori) infection causes a chronic inflammatory reaction that damages the gastric mucosa. T cells (Th), especially Th17 cells, are among the key components of neuro-inflammatory pathways that are activated in H. pylori infection and play their role by secreting cytokines. Clomipramine is a tricyclic antidepressant that has shown immunomodulatory effects in vitro. It reduces the adverse effects of glucocorticoids and pro-inflammatory cytokines and has anti-inflammatory properties. Aim: To determine the level of IL-17A, IL-22, IL-33 and IL-10 in patients with H. pylori infection who affected by clomipramine. Methods: Two biopsy samples were taken from patients with indigestion and sent to the pathology laboratory for rapid urease and histopathology tests. The patient was divided into two groups (infected patients and non-infected patients). PBMC cells were isolated from the blood of participants and clomipramine treatment was evaluated in the cell culture medium. The level of different cytokines in the supernatant was determined using an ELISA kit. Result: IL-10 levels were increased in infected patients with chronic gastritis compared to uninfected groups treated with clomipramine. Also, the level of IL-22 in active chronic gastritis patients increased significantly in the presence of clomipramine compared to the uninfected group. IL-17A and IL-33 levels in chronic gastritis patients did not change in the presence of clomipramine. Conclusion: IIn the present study, the increase in the level of IL-10 in patients with chronic gastritis and no change in the levels of the two inflammatory cytokines IL-17A and IL-33 in gastritis caused by Helicobacter pylori compared to non-infected people, that may be the anti-inflammatory effects of clomipramine.
کلمات کلیدی
Keywords Cytokine, Clomipramine, H. pylori, inflammation
