ارتباط بین سطح سرمی TWEAK و بار پروویروسی HTLV-1 در HAM/TSP
کد: G-1167
نویسندگان: نفیسه طاهری © ℗, سعیده ابراهیمی, هوشنگ رفعت پناه بایگی
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Human T Lymphotropic Virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), the main neurologic manifestation of HTLV-I, is a chronic inflammatory disease. Viral-host interaction and host genetics are two important contributors to the development of the HAM/TSP. This study was conducted to measure the serum level of TWEAK by ELISA method in three groups of participants including 34 HAM/TSP patients (HAM/TSP), 35 asymptomatic HTLV-1 carriers (ACs), and 20 healthy controls (HCs). Also, the titer of the proviral load in two groups of HAM/TSP and ACs was assessed by the real-time PCR. The statistical results showed that, there is no significant difference between the three groups in TWEAK cytokine level (P=0.667). Also, there was no significant difference in proviral load titer between groups of HAM/TSP and ACs (P=0.08). Furthermore, no significant difference was observed between proviral load and TWEAK cytokine concentration between groups of HAM/TSP and ACs. Our findings showed that despite the inflammatory nature of HAM/TSP disease, the expression level of TWEAK in HAM/TSP patients is not significantly different from the groups of ACs and HCs. Therefore, the involvement of other factors in causing HAM/TSP is not unexpected.
کلمات کلیدی
HTLV-1، HAM/TSP، TWEAK، بارپروویروسیHTLV-1
