مقاومت آنتی بیوتیکی پروتئوس جدا شده از نمونه ادرار بیماران اطفال بیمارستان های شهر همدان
کد: G-1176
نویسندگان: سما مکاری ℗, محمد طاهری ©, مرضیه عسکری نیا
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Introduction: Proteus species are common pathogens responsible for urinary tract infections (UTIs) in children. These infections can lead to significant morbidity if not treated effectively. The rising incidence of antibiotic resistance in Proteus species is a growing concern, particularly in hospital environments. This study aimed to assess the antibiotic resistance patterns of Proteus isolates from urine samples of pediatric patients in teaching hospitals across Hamadan. Methods: In this cross-sectional study, urine samples were collected from pediatric patients suspected of UTIs in several teaching hospitals in Hamadan over a six-month period. Proteus isolates were identified using standard microbiological techniques. Antibiotic susceptibility was evaluated using the Kirby-Bauer disk diffusion method. The antibiotics tested included ceftriaxone, ampicillin, ciprofloxacin, trimethoprim-sulfamethoxazole, and gentamicin. Results: The study found that 65% of the Proteus isolates were resistant to ampicillin, while 55% showed resistance to trimethoprim-sulfamethoxazole. Additionally, 40% of the isolates were resistant to ciprofloxacin, and 30% exhibited resistance to ceftriaxone. However, only 15% of the isolates showed resistance to gentamicin. Multidrug resistance (MDR) was detected in 35% of the isolates. Conclusion: The significant levels of antibiotic resistance in Proteus isolates from pediatric urine samples in Hamadan’s teaching hospitals highlight the need for vigilant antibiotic stewardship and continuous monitoring of resistance patterns. Targeted therapy based on susceptibility testing is crucial to ensure effective treatment of UTIs in pediatric patients and to minimize the spread of resistant strains. Further research to explore the underlying causes of resistance and to develop effective preventive strategies is recommended.
کلمات کلیدی
Antibiotic resistance, Proteus species, Urine samples, Pediatric patients
