پتانسیل ضد باکتریایی ترکیبات طبیعی مشتق از جلبک: رویکردی امیدوارکننده برای مبارزه با مقاومت آنتی بیوتیکی
کد: G-1185
نویسندگان: فاطمه نوری © ℗, محمد طاهری
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Background: Natural compounds derived from algae have gained significant attention as potential alternatives to conventional antibiotics, especially in light of the global rise in antimicrobial resistance (AMR). Algae, both macro and micro, produce a wide array of bioactive compounds such as polysaccharides, terpenoids, and phenolic compounds, which exhibit diverse antibacterial properties. This systematic review aims to evaluate the antibacterial efficacy of natural compounds extracted from various algae species, focusing on their mechanisms of action, potential therapeutic applications, and effectiveness against multi-drug resistant (MDR) bacteria. Methods: A comprehensive literature search was conducted across multiple databases, including PubMed, Scopus, Web of Science, and Google Scholar, covering articles published between 2000 and 2023. The search terms included "algal compounds," "antibacterial activity," "antimicrobial resistance," and "natural antibiotics." Studies were selected based on their relevance to algae-derived compounds with demonstrated antibacterial efficacy. Articles discussing the mechanisms of action, biofilm inhibition, and the interaction of algal compounds with conventional antibiotics were included. Data were extracted and analyzed to assess the effectiveness of these compounds against both Gram-positive and Gram-negative bacteria. Results: The review identified several key algal compounds, including phlorotannins, fucoidans, and algal polysaccharides, with significant antibacterial activity. These compounds were particularly effective against MDR strains such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Phlorotannins were noted for their ability to disrupt bacterial cell walls, while fucoidans demonstrated strong biofilm inhibitory properties. Additionally, some compounds exhibited synergistic effects when used in combination with conventional antibiotics, enhancing the overall antibacterial efficacy. Conclusion: Algal-derived compounds hold great promise as alternative or complementary agents to combat bacterial infections, particularly in the context of antibiotic resistance. Their broad-spectrum activity, coupled with mechanisms that differ from conventional antibiotics, positions these natural compounds as valuable resources for developing new antimicrobial strategies. Further research is needed to explore their clinical applications, optimize extraction methods, and evaluate potential side effects to ensure their safe and effective use in medical practice.
کلمات کلیدی
Algal Compounds Antibacterial Activity Natural Antibiotics Antimicrobial Resistance (AMR) Phlorotannins Fucoidans Biofilm Inhibition Multi-Drug Resistant Bacteria (MDR)
