تجزیه و تحلیل مولکولی ویروس لنفوتروپیک سلول T انسانی نوع 1 توسط پلی مورفیسم ساختاری تک رشته ای در شمال شرق ایران (مشهد)
کد: G-1187
نویسندگان: Seyed Sajjad Alavi-Kakhki ℗, Seyed Abdol Rahim Rezaee, Mahmood Bagheri, Kiarash Ghazvini ©
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Background: Human T-lymphotropic virus type 1 (HTLV-1) infection is endemic in the northeastern region of Iran. Molecular subtyping of HTLV-1 is crucial for understanding its transmission pathways and implementing effective prevention strategies. Materials & Methods: The single-strand conformation polymorphism (SSCP) analysis was utilized to evaluate of HTLV-1. The assay was designed to target a highly variable region in the long terminal repeat and was shown to be able to detect single nucleotide changes in HTLV-1. Results: Analysis of 53 HTLV-1 samples showed almost identical SSCP patterns. SSCP results suggesting the presence of similar viral genotypes and, therefore, supporting the likelihood of intercommunity transmission of HTLV-1 in this area. Discussion: This study provides important insights into the molecular epidemiology of HTLV-1 in Northeast Iran, specifically in Mashhad. Using SSCP analysis, a high degree of viral homogeneity was observed, suggesting limited genetic diversity. This likely reflects long-term endemic transmission, primarily through vertical and sexual routes. The relative isolation of the population and the virus's low mutation rate may have contributed to the observed genetic stability. Conclusion: The findings suggest that HTLV-1 has been circulating in this region for an extended period rather than being a recent introduction. This emphasizes the need for targeted public health strategies, including screening and education to prevent further transmission. Future studies should utilize genetic sequencing for a more detailed understanding of HTLV-1's genetic diversity and distribution in Iran.
کلمات کلیدی
HTLV-1, molecular subtyping, SSCP analysis, viral genotypes, genetic diversity, endemic transmission, long terminal repeat, intercommunity transmission
