Aptamer-Enhanced Antimicrobial Peptide Hydrogel: A Targeted Approach for Pseudomonas aeruginosa Eradication in Wound Care
کد: G-1189
نویسندگان: Marzieh Askarinia ℗, Mohammad Taheri ©
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Introduction: Pseudomonas aeruginosa, a common pathogen in chronic wound infections, is notorious for its biofilm formation and resistance to conventional treatments. Aptamers, short oligonucleotides with high affinity for specific targets, have recently emerged as novel binding molecules for enhancing the efficacy of wound dressings. This systematic review focuses on aptamer-functionalized antimicrobial peptide-armored hydrogels for the targeted removal and eradication of P. aeruginosa. Methods: A systematic search was conducted in PubMed, Scopus, and Web of Science databases, covering studies from 2010 to 2023. The key terms used included "aptamers," "Pseudomonas aeruginosa," "antimicrobial peptides," "hydrogel wound dressings," and "biofilm eradication." Studies that evaluated the efficacy of aptamer-hydrogel composites in wound care were included. Results: Aptamer-functionalized hydrogels showed a significant increase in specificity and efficacy in targeting P. aeruginosa biofilms. The antimicrobial peptides incorporated within the hydrogel exhibited broad-spectrum activity, while the aptamers provided high specificity to P. aeruginosa, allowing for selective removal of the pathogen. The hydrogel matrix also contributed to sustained release of the antimicrobial peptides, improving overall wound healing outcomes. Conclusion: The combination of aptamers and antimicrobial peptides in hydrogel dressings represents a novel and effective approach for treating P. aeruginosa infections. This targeted treatment strategy could revolutionize wound care by improving specificity and minimizing off-target effects.
کلمات کلیدی
Aptamer, Pseudomonas aeruginosa , Wound Care
