Development of a Closed-Loop Biocompatible Biopolymer Patch for Real-Time Detection and Prevention of Chronic Wound Infections
کد: G-1190
نویسندگان: Marzieh Askarinia ℗, Mohammad Taheri ©
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Introduction: Chronic wound infections are a growing concern due to their prolonged healing times and risk of developing into life-threatening conditions. The integration of biopolymer-based wound dressings with biosensors offers a cutting-edge solution for real-time infection monitoring and prevention. This systematic review examines the current progress toward developing closed-loop, biocompatible wound dressings that detect infections and deliver targeted treatment. Methods: A literature search was performed in databases including PubMed, Scopus, and Google Scholar for studies published between 2011 and 2023. Keywords included "closed-loop wound dressing," "biopolymer," "infection detection," and "biosensor." Inclusion criteria were studies that reported on biocompatible wound dressings with integrated sensors for infection detection and prevention. Results: Closed-loop biopolymer dressings demonstrated enhanced wound healing due to their ability to detect infection via pH changes and other biochemical signals. Once an infection was detected, the dressings responded by releasing antimicrobial agents embedded in the biopolymer matrix. Studies showed that these dressings were highly effective in preventing bacterial colonization, especially in chronic wound environments, and in delivering sustained antimicrobial therapy. Conclusion: The development of closed-loop, integrated biopolymer wound dressings offers a promising solution for managing chronic wound infections. These smart dressings not only detect the early onset of infection but also respond with precise antimicrobial intervention, improving patient outcomes
کلمات کلیدی
Chronic, Wound, Infections, Biocompatible, Biopolymer
