انتروباکترالهای تولیدکننده بتالاکتاماز با طیف گسترده جدا شده از بیماران مشکوک به عفونت خون
کد: G-1210
نویسندگان: Abbasi Pejman © ℗, Gholamreza Pouladfar, Bahman Pourabbas, Zahra Jafarpour, Amin Abbasian, Mohammad Ali, Dehyadegari, Helma Nasiraei, Helma Nasiraei, Sara Dorost Kar
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Introduction and objectives: Extended-spectrum beta-lactamases (ESBL) are enzymes that confer resistance to most beta-lactam antibiotics, including penicillin, cephalosporin, and the aztreonams. An alarming increase in the occurrence of ESBL has threatened the treatment and management of bloodstream infections. Bloodstream infections (BSIs) are associated with high morbidity and mortality worldwide, in both developed and developing countries. The aim of the study investigates the prevalence of ESBLs among different members of Enterobacterales in Shiraz, Iran. Materials and Methods: A retrospective study was carried out to determine the epidemiology of Enterobacterales in the blood culture isolates registered to Professor Alborzi Clinical Microbiology Research Center Shiraz, Iran, from March 2022 to March 2024. The isolates were identified by standard biochemical test and biochemical tests embedded in the API-20E biochemical kit system were used for final confirm. Susceptibility testing (disc diffusion) was performed according clinical and laboratory standards institute (CLSI) guidelines. Phenotypic detection of extended spectrum beta-lactamase producing isolates was performed by double disk synergy test (DDST). Results: Total 367 member of family of Enterobacterales isolated, that among them 327 (89.1 %) were ESBL producers. The most common isolates were ESBL producers Klebsiella spp. (37%), Escherichia coli (34%), Enterobacter spp. (25%). Klebsiella spp. was the most common ESBL-producing isolate (37%) of isolates were ESBL positive. ESBL producers exhibited a high resistance rate to ampicillin (99.7%), cefuroxime (99.1%), cefotaxime (94.1%), amoxicillin/clavulanic acid (77.5%), and trimethoprim/sulfamethoxazole (73.3%). Conclusion: Extended-spectrum-β- Lactamase (ESBL)-producing Enterobacterales bloodstream infections represent a worldwide clinical issue, especially given their association with multidrug resistance, severity of illness, poor outcomes, and growing number in the community. Our data make obvious the high prevalence of ESBL producers in K. pneumoniae and E. coli BSI in hospitals in shiraz, Iran, confirming the Multi drug resistance strains are increasing and treatment of infections causing by this isolate are major problem in Iran.
کلمات کلیدی
Enterobacterales - Bloodstream Infection - Shiraz
