شیوع عوارض جنینی و مادری ناشی از COVID-19 در زنان باردار بستری در بیمارستان
کد: G-1022
نویسندگان: Ashraf Tavanaee Sani ℗, Mahnaz Boroumand Rezazadeh, Arash Ziaee ©
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
BACKGROUND The global COVID-19 pandemic has profoundly impacted pregnant mothers and their newborns; while pregnant women essentially exhibit similar symptoms to non-pregnant individuals, they differ in specific clinical manifestations, and a notable portion remains asymptomatic. This study aims to explore the interrelations between assorted maternal laboratory findings and symptoms concerning maternal and neonatal outcomes associated with COVID-19. METHOD This study examined the effects of COVID-19 on childbirth by analyzing data from pregnant women who tested positive for COVID-19 and delivered at Imam-Reza Hospital in Mashhad, Iran, between April 2021 and March 2022. The data acquired included demographic, physical, laboratory, symptom, maternal outcome, and neonatal outcome variables. The data underwent comprehensive preprocessing. Variable interactions were explored using partial correlation analysis and logistic regression modeling. RESULTS Using logistic regression, in this retrospective analysis of 293 mothers and their offspring, the key findings were that for preterm delivery, lower lymphocyte percentage, platelet count, and higher prothrombin time were significant independent risk factors while advancing gestational age were protective (OR 0.94). Higher maternal weight (OR 0.04) and lower CRP (OR 0.077) emerged as protective factors for intrauterine growth restriction. Stillbirth risk significantly increased with elevated ferritin (OR 10.116) and prothrombin time (OR 6.341), but higher respiratory rate (OR 0.211) and later gestational age (OR 0.781) were protective. Neonatal asphyxia was associated with increased maternal height (OR 3.67) and respiratory rate (OR 4.702), while higher lymphocyte percentage was protective (OR 0.214). Across outcomes, lower lymphocyte percentage consistently predicted higher odds of adverse events like ICU admission (OR 0.421), low birth weight (OR 0.435), and mechanical ventilation (OR 0.311). CONCLUSION Our study offers important insights into the relationship between COVID-19 in pregnant women and outcomes for mothers and newborns. Key findings highlight the roles of inflammation, coagulation, and immune response in predicting adverse events. Overlooked factors like respiratory rate and maternal height may have predictive value. Compared to other research, notable differences emerge, suggesting areas for further study.
کلمات کلیدی
COVID-19; Pregnancy; Maternal health; Neonatal health; Adverse outcomes; Predictive factors
