پیشگیری از سیتومگالوویروس در گیرندگان پیوند کبد: مطالعه تطبیقی استراتژی های جهانی و پیشگیرانه با والگانسیکلوویر
کد: G-1034
نویسندگان: Rozita Khodashahi © ℗, Mohsen Aliakbarian
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Objective: Universal prophylaxis and preemptive therapy have been utilized to prevent and treat cytomegalovirus (CMV) infection in post-transplant cases, respectively. This study aimed to compare universal prophylaxis with valganciclovir to preemptive treatment in liver transplant recipients. Methods: This retrospective cross-sectional study was conducted between 2013-2021, on patients received valganciclovir after liver transplantation in Mashhad, Iran. Patients were categorized into: 1. Universal (n=170), 2. Preemptive treatment (n=305), using an available sampling method. Results: There was no significant difference in CMV infection between the groups. Preemptive group had greater average age at transplantation than universal group (P0.05). The CMV immunoglobulin G (IgG) test showed a strong connection in both groups (P0.05). The mean of hemoglobin and total bilirubin differed between groups (P0.05). No significant statistical relationship was found between gender, graft rejection, time of CMV infection, patients' discharge status, personal satisfaction, death, cause of death, type of concurrent opportunistic infection, Epstein-Barr virus IgG and polymerase chain reaction (PCR), Mycobacterium tuberculosis PCR, purified protein derivative (PPD), and blood culture test result. Conclusion: Both treatment methods are equally effective in preventing CMV disease, graft rejection, CMV infection rates, and the overall status of liver transplant recipients in terms of discharge, death, and opportunistic infections.
کلمات کلیدی
Mycobacterium tuberculosis, Tuberculin, Blood Culture, Epstein-Barr Virus Infections, Graft Rejection, Immunoglobulin G, Hemoglobins, Bilirubin
