تأثیر واکسیناسیون کووید-19 بر مرگ و میر بیماران بستری در بیمارستان مبتلا به نوع Omicron
کد: G-1035
نویسندگان: Rozita Khodashahi © ℗, Mohsen Aliakbarian
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Introduction: The Omicron variant of SARS-CoV-2 has sparked concerns regarding its public health implications. Vaccination remains a critical measure in preventing and controlling COVID-19 and future similar outbreaks. This research investigates the effect of COVID-19 vaccination on the mortality rates of hospitalized patients infected with the Omicron variant, offering insights into vaccine effectiveness and informing public health policies. Methods: Conducted between January 2021 and September 2022, this study examined characteristics, clinical presentations, comorbidities, and mortality factors among COVID-19 patients in hospitals under Mashhad University of Medical Sciences in Iran. Data was gathered from the Medical Care Monitoring System, incorporating information from six medical universities. A total of 8,616 hospitalized COVID-19 patients were analyzed, with particular focus on their vaccination status (vector-based and non-vector-based vaccines) and its relationship to Omicron variant infection using logistic regression. Subgroup analyses were also performed to identify potential effect modifiers. Variables considered included age, gender, time from symptom onset to hospitalization, oxygen saturation, duration of hospital stay, and underlying health conditions. Results: Age was found to be a significant predictor of mortality in hospitalized patients, while higher oxygen saturation levels correlated with better survival rates. Interestingly, prolonged hospital stays were linked to an increased mortality risk, possibly due to hospital-acquired infections. Booster vaccinations played a key role in lowering mortality, particularly in cases involving the Omicron variant, with specific vaccine formulations showing marked benefits. Comorbid conditions like diabetes and hypertension were associated with an elevated risk of death. Conclusion: This study highlights the relationship between COVID-19 vaccination, patient demographics, comorbidities, and hospitalization outcomes. Mortality risk was influenced by factors such as age, oxygen levels, and booster doses, while extended hospital stays and pre-existing conditions increased the likelihood of death. The findings emphasize the importance of ongoing research and standardized vaccine classification in addressing the pandemic.
کلمات کلیدی
COVID-19, Omicron variant, Vaccine efficacy, Mortality, Hospitalized patients
