مقایسه میزان دی دایمر، فاکتورهای التهابی و آنزیم های کبدی در بیماران 19COVID- در دو پیک آلفا و دلتا
کد: G-1038
نویسندگان: Zahra Mobarezi ℗, Samane Motamedi, Masoud Youssefi, Majid Khadem-Rezaiyan, Farnaz Zahedi Avval ©
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Objective: The status of COVID-19 in peak 4 (alpha variant) and peak 5 (delta variant) can show the prognostic difference of patients with alpha and delta strains and provide the ability to predict the behavior of the strains in the next probable waves. Therefore, the present study was conducted in order to compare the amount of D-dimer, inflammatory factors including CRP, and liver enzymes in hospitalized patients of Mashhad COVID-19 in two peaks. Method: This cross-sectional study was conducted on all hospitalized COVID-19 patients during the peaks 4 and 5 of the disease. The information related to the studied variables including D-dimer, CRP and liver enzymes and background information including age, gender and hospitalization date to define the peak were extracted from the electronic files of the patients. Finally, the obtained information was analyzed by SPSS statistical software. Findings: Totally 5751 patients with mean age of 58.92 ± 17.69 years were included in the study, of which 2975 patients (51.7%) were male and 2776 patients (48.2%) were female. The gender composition of the two groups (peak group 4 and peak group 5) was similar to each other, while the age of patients in peak 4 was significantly higher than peak 5 (p0.001). In the fourth peak, the CRP level was significantly higher than the fifth peak (p0.001) and the ALT level was significantly lower than the fifth peak (p=0.042). However, in other cases, there was no significant difference between the two peaks. ALT level was significantly higher in male patients than in female patients (p=0.015), but no significant difference was observed in other laboratory factors between the two genders. Conclusion: Based on the results obtained in the present study, in the fifth peak, the CRP level has decreased. This can be due to updating treatment protocols and improving the level of medical services. However, ALT levels was elevated in peak 5, indicating more liver damage that can be due to systemic inflammation, direct viral cytopathic effects, and drug-induced hepatotoxicity.
کلمات کلیدی
COVID-19 , Inflammatory Factors, D-dimer, CRP, liver enzymes
