پراکندگی ژنوتیپ های ویروس پاپیلوما انسانی در نمونه های زگیل تناسلی و مایع منی جمع آوری شده از جمعیت استان فارس
کد: G-1050
نویسندگان: Mahtab Kalani ℗, Fatemeh Mirzaei, Haniyeh Keyghobadi, Gholamhossein Keighobadi, Atefeh Raoofat, Mehdi Kalani ©, Ali Moravej
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Introduction Regarding the importance of HPV vaccination in the prevention of HPV infection outcomes such as cervical cancer, determining the distribution of HPV genotypes in the community is critical to setting the policy to decrease the disease outcomes. So, we aimed to detect the prevalence of the common HPV genotypes in the anogenital warts and semen specimens collected from the Fars province population. Methods and materials Seventy-two samples including 54 tissues and 18 semen were included in the study, and DNA was extracted from the specimens using DNA extraction kits and 21 HPV genotypes were detected using real-time PCR methods based on the manufacturer’s instruction. The results were analyzed using the R programming package version 4.3.3 and SPSS version 23. Results HPV genotyping was conducted on 35 (48.6%) males and 37 (51.4%) females samples with age mean ± SD; 32.46 ± 8.55, and 34.43 ± 13.45 years, respectively. The warts specimens were collected from 17 (31.5%) males and 37 (68.5%) females. The tissue samples were from 18 penile (33.3%), 12 anal (22.2%) and 24 vaginal (44.4%) warts. Of warts, 38 (70.4%) samples were positive, among them, 23 (60.5%) and 15 (39.5%) tissues were positive with single and multiple HPV genotypes, respectively. From the semen, 10 (55.6%) samples were positive that infection with single or various genotypes was observed in 6 (60%) and 4 (40%) positive samples, respectively. Together, infection with 1, 2, 3, 4, and 5 HPV types were observed in 29 (60.4%), 12 (25%), 3 (6.2%), 1 (2%), and 5 (10.4%) of positive samples, respectively. Among HPV genotypes, HPV 6 was the most frequent type with a frequency of 34 (37%) which were detected in 29 warts and 5 semen samples. The frequency of high-risk genotypes 16 and 18 were 5 (6.3%) detected in 3 and 4 warts and 4 and 1 semen samples, respectively. Collectively, 15 different HPV genotypes were detected in the warts and semen samples. Conclusion: Since HPV is known as the most common cause of sexually transmitted diseases, we detected 15 different HPV types in the anogenital and semen samples, and only 9 of them
کلمات کلیدی
HPV genotype, Anogenital warts, Semen, Fars province
