نتایج بالینی و یافته های آزمایشگاهی در بیماران تحت درمان با آسیکلوویر: یک مطالعه مقایسه ای
کد: G-1062
نویسندگان: Nasrin Aliabadi ℗, Nahid Heydari, Marzieh Hosseini, Zahra Jafarpoor, Gholamreza Pouladfar ©, Sara Dorostkar
زمان بندی: زمان بندی نشده!
دانلود: دانلود پوستر
خلاصه مقاله:
خلاصه مقاله
Background: Acyclovir is a commonly used antiviral medication for the treatment of various viral infections. This study aimed to investigate the clinical characteristics, laboratory findings, and outcomes of patients treated with acyclovir compared to those who did not receive the drug. Methods: A total of 95 patients were included in the study, with 57 receiving acyclovir and 38 not receiving the drug. Demographic data, clinical characteristics, reasons for ICU admission, CSF analysis, EEG findings, brain imaging results, and outcomes were compared between the two groups. Results: Patients treated with acyclovir had a significantly longer hospital stay (median 20 days vs. 11 days, p=0.005) and were more likely to experience loss of consciousness (54.4% vs. 28.9%, p=0.014). Acyclovir patients had higher levels of albumin (median 2.8 vs. 0, p=0.028) and AST (median 24 vs. 0, p=0.037) in their blood. CSF analysis revealed higher total cell counts (median 90 vs. 9, p=0.043), leukocyte counts (median 3 vs. 0, p=0.009), and lymphocyte counts (median 30 vs. 0, p=0.008) in the acyclovir group. Abnormal CT scans were more common in the non-acyclovir group (77.8% vs. 50%, p=0.144), while abnormal MRI findings were more prevalent in the acyclovir group (67.9% vs. 20.8%, p=0.507). Recovery rates were similar between the two groups (59.2% for acyclovir vs. 40.8% for non-acyclovir, p=0.950). Conclusion: This study shows that acyclovir treatment is recommended for patients with adverse neurological conditions. Therefore, the results revealed a potential relationship between acyclovir treatment and adverse neurological outcomes, characterized by loss of consciousness, increased albumin and AST levels, and changes in CSF parameters. These findings warrant further research to clarify its clinical significance and inform optimal management strategies for patients receiving acyclovir therapy.
کلمات کلیدی
A cyclovir, Herpes simplex Encephalitis, Antiviral
