مروری بر ارتباط مقاومت آنتی بیوتیکی و عفونت زخم محل جراحی
کد: G-1084
نویسندگان: Hamed Azad ℗, Arian Ghasemi ©, Alireza Shabani, Seyed Masoud Hashemi Karoii, Azin Aghajani Amiri
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خلاصه مقاله:
خلاصه مقاله
As warned by Sir Alexander Fleming in his Nobel Prize lecture: “The use of antimicrobials can, and will, lead to resistance“. Bacteria are simple and adaptable microorganisms able to change themselves when the conditions of their environment are no longer privileged, for example, in the presence of antibiotics. Therefore, antimicrobial resistance (AMR) has to be regarded as a natural phenomenon to which any antibiotic provides. The AMR threat happens due to the overuse and misuse of antibiotics, often unnecessarily or without a prescription. Additionally, the use of antibiotics in animals (food-producing, companion, or exotic) has significantly granted to the selection and transmission of resistant bacteria. Unfortunately, even proper administration of antibiotics is eventually associated with developing resistance, usually within 1 to 2 decades of introducing a particular drug. In some cases, it comes within 3 to 4 years. Globally, the threat and costs of AMR are widely acknowledged. For example, antibiotic-resistant pathogens result in approximately 33,000 deaths per year in Europe and 4.95 million total deaths worldwide, resulting in EUR 1.5 billion in healthcare expenses and productivity losses annually. The World Health Organization (WHO) considers AMR “one of the ten global public health threats facing humanity” based on the predictions that by 2050, it will be accountable for more than 10 million deaths per year, with a loss of more than 100 trillion dollars worldwide. Surgical site infections (SSI) pose a significant public health challenge to the effectiveness of surgical procedures worldwide, particularly in developing nations. The issue lies in the strong connection between surgical site infections (SSI) and the growing challenge of antimicrobial resistance, a situation worsened by the misuse of antibiotics in surgical prophylaxis and inadequate infection prevention and control practices. In this review, we discuss the correlation of AMR with SSI in both Human and veterinary Medicine and its impact on public health.
کلمات کلیدی
antimicrobials-Resistance, Surgical Site Infection, AMR, SSI.